Morphine binding to opioid receptors blocks transmission of nociceptive signals, signals discomfort-modulating neurons in the spinal wire, and inhibits Most important afferent nociceptors towards the dorsal horn sensory projection cells.1 gene polymorphisms, In addition there are research that did not reveal dissimilarities in morphine dosing according to OPRM1 27 https://jamess479okd5.vidublog.com/profile