At this time, there are two kinds of studies on itaconate: Irg1−/− macrophages and the regulatory effect of itaconate derivatives. These two results ended up complementary and unveiled which the regulatory mechanisms of itaconate included alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription issue three (ATF3) induction https://klausp877zku9.blogoscience.com/profile