There's a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to decrease afferent pain transmission and produce analgesia. As a result, medicine like clonidine that concentrate on alpha-2 receptors can impact the transmission of ache. Could be given as monotherapy https://janetg394cxo9.illawiki.com/user