Circulating cortisol fluctuates diurnally under the control of the "master" circadian CLOCK. while the peripheral "slave" counterpart of the latter regulates the transcriptional activity of the glucocorticoid receptor (GR) at local glucocorticoid target tissues through acetylation. In this manuscript. we studied the effect of CLOCK-mediated GR acetylation on the sensitivity of periphe... https://www.bekindtopets.com/