You will find a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors within the dorsal horn to decrease afferent soreness transmission and make analgesia. Thus, medication like clonidine that target alpha-2 receptors can affect the transmission of soreness. Clonidine is a lengthy-time period medication. https://www.proleviate.com/post/the-new-pain-killer-conolidine