Finally, clonidine enhances neuraxial opioids and, in combination with fentanyl, interacts within an additive method, which can lessen the dose of each and every element by 60% for postoperative analgesia. Clonidine treats substantial blood pressure by stimulating α2 receptors inside the brainstem, which decreases peripheral vascular resistance, reducing hypertension. https://www.proleviate.com/post/the-new-pain-killer-conolidine