There is a release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to reduce afferent discomfort transmission and create analgesia. Hence, medication like clonidine that target alpha-2 receptors can influence the transmission of pain. Relates to clonidine: oral tablet, oral tablet https://www.proleviate.com/post/the-new-pain-killer-conolidine